Foretelling the ‘Dreaded Disease:’ A Panel Discussion About Communicating with Patients in the Era of Pre-Screening and Early Cancer Detection

On June 10, 2022, The New York Times told the stories of Jim Ford and Susan Iorio Bell.

After an experimental biomarker-based blood test detected Mr. Ford’s asymptomatic pancreatic cancer at an early stage, physicians used surgery, chemotherapy, and radiation to destroy it, likely saving his life.

A similar test found a cancer-associated protein circulating in Ms. Bell’s blood. But imaging tests revealed no signs of a tumor. Ms. Bell remains shaken by her prospects of developing a disease that has already afflicted both her parents.

Mr. Ford and Ms. Bell’s experiences spotlight both the promise and the potential pitfalls of genetic pre-screening and blood-based early detection tests in cancer care. By identifying people whose bodies express cancer-related biological signals sooner, these tools could help physicians and patients get ahead of the second-leading cause of death in the United States. But widespread clinical adoption may also leave some patients with positive test results of uncertain significance, raising unanswered questions about if and when the “dreaded disease” may take hold. Patient-provider communication will play a key role in maximizing medical opportunities while mitigating patient anxieties in this new era of cancer care.

A patient will share views and questions about the risks and benefits of pre-screening and early detection in cancer care. Test developers and medical experts will respond.

  • Moderator

    William Dalton, Ph.D., M.D.
    Founder and Senior Advisor , M2Gen

  • Panelist

    David Bakelman
    CEO, National Pancreas Foundation

  • Panelist

    Kevin Conroy
    CEO, President, Chairman of the Board, Exact Sciences

  • Panelist

    Robert C. Green, M.D.
    Professor of Medicine (Genetics, Director, Genomes2People Research, Harvard Medical School

  • Panelist

    Joshua Ofman, M.D., MSHS
    President, GRAIL

  • Panelist

    Sapna Syngal, M.D.
    Strategic Planning Director, Prevention and Early Detection, Dana Farber Cancer Institute